Thrombophilia and thrombosis

Maternal thrombophilia and neonatal thrombosis.

In neonates and infants, numerous clinical and environmental conditions lead to elevated thrombin generation and subsequent thrombus formation. Genetic prothrombotic defects (protein C, protein S and antithrombin deficiency, mutations of coagulation factor V and factor II, elevated lipoprotein (a)) have been established as risk factors of thromboembolic events in neonates and infants. The inter...

Thrombophilia testing, recurrent thrombosis, and women's health.

Unusual forms of venous thrombosis and thrombophilia.

Venous thromboembolism (VTE) results from multiple interactions between inherited and environmental risk factors. The lower limbs are the most common site of VTE, but more rarely other venous sites can be involved. The role of risk factors for VTE can be different in the various thrombotic manifestations, and there are specific risk factors for specific sites. Coagulation abnormalities causing ...

Heritable Thrombophilia and Pregnancy Associated Thrombosis.

Venous thromboembolism VTE is the major cause of morbidity and mortality in pregnant woman in industrialized countries. VTE is said to occur at the rate of about 1 per 1000 pregnancies[1,2]. It is important to note that the frequency of asymptomatic DVT is probably not negligible specially in multiparity women as shown by the results of the Sirius Study in which multiparity was found to be a ri...

Recurrent Deep Vein Thrombosis due to Thrombophilia

Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of...